The 5th Global High-Level Ministerial Conference on Antimicrobial Resistance (AMR) will bring together ministers, policymakers and stakeholders from around the world to review progress, strengthen political commitment and accelerate action against the growing threat of AMR. Under the theme One Health: Advancing Global AMR Commitments through Local Action, the conference will explore how countries and partners can work together across human, animal, plant and environmental health to prevent and address AMR. Discussions will focus on translating global commitments into practical action, improving access to essential antimicrobials and diagnostics, strengthening prevention efforts and mobilising sustainable financing. Taking place in Abuja, Nigeria, from 6–8 December 2026, the conference will be the first of its kind hosted on the African continent, offering an important opportunity to amplify African perspectives and advance more equitable, inclusive and sustainable global responses to AMR.